Today’s modern and industrial trade processes are influenced by globalization and the Philippines is not exempted to this. It must now exhaust all of its resources to be competitive and acquire a bigger share of the foreign market. As the second largest island in the Philippines, Mindanao has a vast area that is suitable for industry, tourism and agribusiness. Sadly, there are many areas in the region that have long been poor and underdeveloped in terms of infrastructure for business and investment yet are home to existing agribusiness and industrial commodities that are perfect for foreign trading. This article investigates the perceived effects of globalization on trade and investment in the Mindanao Muslim areas. It also looks at how the types of business engaged in by the Mindanao Muslims affect the foreign investment opportunities in the region.