New, innovative, and emerging technologies are being used more than ever across homes, factories, farms, cities, and nations. These are disrupting traditional commerce and business models, thus ushering the Fourth Industrial Revolution (FIRe). This Policy Note describes how frontier technologies of the FIRe are altering patterns of consumption and production, which are not only resulting in opportunities for productivity growth but also heralding a lot of uncertainty, including likely unintended consequences. As such, it urges the government to take a decisive action, particularly in instituting regulatory reforms, in preparing our current and future workforce for future jobs, and in strengthening social protection to counter the likely negative effects of the FIRe. It also calls for the development of a whole-of-nation paradigm and action agenda, which can serve as a framework for assessing possibilities and alternative policies and a guide to improve our readiness for the future today.